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    熊文勇

    来源: 日期:2019年07月22日 15:23点击:

    熊文勇

    邮箱:xwy@ynu.edu.cn

    职称:研究员(博士生导师)

    地址:伟德国际1946源于英国呈贡校区伟德BETVlCTOR1946,国家重点实验室11403

    教育经历

    1999.09-2004.08,中国科学院昆明动物研究所,动物学, 理学博士

    1995.09-1999.07,陕西师范老员工命科学学院,理学学士

    工作经历

    2023.05-至今, 伟德国际1946源于英国,伟德BETVlCTOR1946,研究员

    2021.05-2023.04,伟德国际1946源于英国,教育部自然资源药物化学重点实验室,研究员

    2011.03-2021.04,中国科学院昆明植物研究所,西部植物资源与持续利用国家重点实验室,研究员

    2007.07-2011.02,美国康奈尔大学Weill医学院,生物化学系, 博士后

    2004.09-2007.06,美国南加州大学Keck医学院,生理与神经科学系/Zilkha神经遗传研究所,博士后

    研究领域

    药用植物及天然产物在治疗代谢性疾病(肥胖、2型糖尿病、高血脂、非酒精性脂肪肝等)中的药效及药理机制研究;调控2型糖尿病等代谢性疾病的分子机制研究。

    奖励荣誉和学术任职

    中国科学院“百人计划”

    云南省“高端科技人才”

    《中国药理学通报》青年编委会委员

    执教课程与教学成果

    主讲研究生《化员工物学进展》、本科生《药物毒理学与病理学》

    科研项目

    国家自然科学基金面上项目,2013.01-2016.12LLGL1 调控小GTP酶在胰岛素诱导GLUT4 膜转运中的机制研究,主持

    中国科学院-百人计划人才项目,2013.1.1-2016.12.31,治疗二型糖尿病的天然化合物筛选与分子作用机理研究,主持

    云南省基础研究计划-高端科技人才项目,2014.01-2018.12治疗2型糖尿病先导化合物的发现及作用机制研究,主持

    云南省基础研究计划-重点项目,2017.06-2020.05一种天然倍半萜化合物的抗2型糖尿病机理研究,主持

    国家重点研发计划,2020.12-2023.11,滇缅地区特有传统药用植物的活性物质基础及其转化研究,参与

    代表性论文

    1)      Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao*, Qian Wang*, Wenyong Xiong*. Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue. Eur. J. Pharmacol. 2023, 956:175942.

    2)      Qian Wang#, Guilin Hu#, Qian Lu, Defu Hong, Abdulbaset Al-Romaima, Minghua Qiu*, Wenyong Xiong*. Identification and screening of novel diterpenoids of roasted arabica coffee in regulating lipid content of white adipocytes. Food Funct. 2023. 14(11):5138-5150.

    3)      Wanying Qin#, Ting Zhang#, Mingxia Ge, Huimin Zhou, Yuhui Xu, Rongfang Mu, Chaoguang Huang, Daowei Liu, Bangrui Huang, Qian Wang, Qinghua Kong, Qingpeng Kong*, Fei Li*, Wenyong Xiong*. Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance.  J. Endocrinol. 2022, 254(3), 151-165.

    4)      Dao-Wei Liu#, Yan-Song Ye#, Chao-Guang HuangQian LuLing YangQian WangHuan WangXia LiuChuan-Bo JingGang Xu*, Wen-Yong Xiong*. Sampsonione F suppresses adipogenesis via activating p53 pathway during the mitotic clonal expansion progression of adipocyte differentiation. Eur. J. Pharmacol. 2022, 925, 175002.

    5)      Xing-Rong Peng#, Qian Wang#, Hai-Guo Su, Lin Zhou, Wen-Yong Xiong* and Ming-Hua Qiu*. Anti-Adipogenic Lanostane-Type Triterpenoids from the Edible and Medicinal Mushroom Ganoderma applanatum. J. Fungi 2022, 8(4), 331.

    6)      Xing-Rong Peng#, Qian Wang#, Hui-RongWang, Kun Hua, Wen-Yong Xiong*, Ming-Hua Qiu*. FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma. Bioorg. Chem. 2021, 116, 105338.

    7)      Hai-Guo Su#, Qing Wang#, Lin Zhou, Xing-Rong Peng*, Wen-Yong Xiong*, Ming-Hua Qiu*. Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents. Bioorg. Chem. 2021, 112, 104977.

    8)      Li-bin Wang#, Dan-ni Wang#, Li-gang Wu, Jia Cao, Jin-hai Tian, Rong Liu, Rong Ma, Jing-jing Yu, Jia Wang, Qi Huang, Wen-yong Xiong*, Xu Zhang*. Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway. Int. J. Biol. Sci. 2021, 17(4), 995-1009.

    9)      Hai-Guo Su#, Qian Wang#, Lin Zhou, Xing-Rong Peng*, Wen-Yong Xiong*, Ming-Hua Qiu*. Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes. Bioorg. Chem. 2020, 104, 104263.

    10)   Qian Wang, Rong-Fang Mu, Xing Liu, Hui-Min Zhou, Yu-Hui Xu, Wan-Ying Qin, Chong-Ren Yang, Li-Bin Wang*, Hai-Zhou Li*, Wen-Yong Xiong*. Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) F.H. Chen That Function in Treatment of Hyperlipidemia and Obesity. J. Agric. Food. Chem. 2020, 68(17), 4865-4875.

    11)   Fang Wang#, Xiaoyan Yang#, Yanting Lu, Zhenghui Li, Yuhui Xu, Jing Hu, Jikai Liu* and Wenyong Xiong*. The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake. J. Biol. Chem. 2019, 294(27), 10415-10427.

    12)   Yangang Pan#, Yuebin Zhang#, Pianchou Gongpan#, Bin Wang, Bingqian Xu, Yuping Shan*, Wenyong Xiong*, Guohui Li* and Hongda Wang*. Single molecule glucose transporting process revealed by force tracing and molecular dynamics simulations. Nanoscale Horiz. 2018, 3(5), 517-524.

    13)   Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong*, Jing Gao,* Hongda Wang*. Mechanistic insights into GLUT1 activating and clustering revealed by super-resolution imaging. PNAS 2018, 115 (27), 7033-7038.

    14)   Yuhui Xu, Yanfen Niu, Yuan Gao, Fang Wang, Wanying Qin, Yanting Lu, Jing Hu, Li Peng, Jikai Liu*, and Wenyong Xiong*. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice. J. Nat. Prod. 2017, 80(8), 2319−2327.

    15)   Lan Gao, Junling Chen, Jing Gao, Hongda Wang*, Wenyong Xiong*. Super-resolution microscopy reveals the reorganization of GLUT4 on plasma membrane regulated by insulin resistance. J. Cell Sci. 2017, 130, 396-405.

    16)   Junling Chen, Tianzhou, Liu, Jing Gao, Lan Gao, Lulu Zhou, Mingjun Cai, Yan Shi, Wenyong Xiong, Junguang Jiang, Ti Tong*, Hongda Wang*. Variation in carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging. Adv. Sci. 2016, 3(12), 1600270.

    17)   Qinghua Kong#, Lan Gao#, Yanfen Niu, Pianchou Gongpan, Yuhui Xu, Yan Li*, Wenyong Xiong*. RACK1 is required for adipogenesis. Am. J. Physiol.-Cell. Ph. 2016, 311(5), C831-C836.

    18)   Darren J Michael#, Wenyong Xiong#, Xuehui Geng, Peter Drain and Robert H Chow*. Human Insulin Vesicle Dynamics during Pulsatile Secretion. DIABETES 2007, 56(5), 1277-1288.

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