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    雷祖海

    来源: 日期:2024年04月01日 08:59点击:

    雷祖海

    邮箱:lei_zuhai@fudan.edu.cn

    职称:教授(博士生导师)

    地址:伟德国际1946源于英国呈贡校区伟德BETVlCTOR1946,国家重点实验室11121

    课题组主页:https://www.x-mol.com/groups/Lei_zuhai

    教育经历

    2012.09-2017.6,华东理工大学,药学,博士

    2008.09-2012.06,华东理工大学,制药工程,学士

    工作经历

    2024.03-至今, 伟德国际1946源于英国,伟德BETVlCTOR1946,教育部自然资源药物化学重点实验室,教授

    2020.03-2024.03,复旦大学,伟德BETVlCTOR1946,青年研究员(博士生导师)

    2018.01-2020.02,复旦大学,化学系,博士后

    2017.06-2017.12,上海药明康德新药开发有限公司,高级研究员

    研究领域

    1. 开发用于生物医学应用的高性能长波长荧光染料,小分子探针

    2. 小动物活体光学成像与传感分析,即时诊断试剂开发

    3. 结合光学成像展开药学相关研究

    奖励荣誉和学术任职

    上海市科技启明星,2022

    博新计划,2018

    执教课程与教学成果

     

    科研项目

    1)      国家自然科学基金面上项目,基于平面化分子内电荷转移机制的短波红外荧光染料研究,NO. 223780722024-2027,主持

    2)      国家自然科学基金面上项目,比率型NIR-II荧光探针的构建及其在肿瘤微环境可视化中的研究,NO. 221740232022-2025,主持

    3)      国家自然科学基金青年项目,近红外二区荧光染料的创制及其在生物影像中的应用研究,NO. 219080302020-2022,主持

    4)      上海市科委科技计划,跨尺度多维度高时空分辨红外荧光活体成像仪, NO. 20S319037002020-2023,主持

    5)      中国博士后创新人才支持计//中国博士后科学基金面上资助项目(一等),NO. BX20180063/2018M6303982018-2020,主持,

    代表性论文

    1)      Qingchun Lan, Peng Yu, Kui Yan, Xiaomin Li, Fan Zhang, Zuhai Lei*, Polymethine Molecular Platform for Ratiometric Fluorescent Probes in the Second Near-Infrared Window, J. Am. Chem. Soc. 2022, 144, 21010-21015. (IF = 15.0,中科院Itop)

    2)      Xuan Zhao, Junfeng Cheng, Lu Zhang, Baofeng Yun, Kui Yan, Bin Wu, Xiao Liu, Fan Zhang, Zuhai Lei*, Near-Infrared II Emissive Diphenylaminoacridine Based on the Planarized Intramolecular Charge Transfer Mechanism, Cell Rep. Phys. Sci. 2023, 4, 101691. (IF = 8.9JIF分区I)

    3)      Xin Zhang, Ying Chen, Haisheng He, Shangfeng Wang, Zuhai Lei*, Fan Zhang*, ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing, Angew. Chem. Int. Ed., 2021, 60, 26337-26341. (IF = 16.6,中科院Itop)

    4)      Meng Lv+, Yang Yu+, María E. Sandoval-Salinas+, Jianhua Xu, Zuhai Lei*, David Casanova*, Youjun Yang*, Jinquan Chen*. Engineering Charge Transfer State to Facilitate Spin-orbit Charge Transfer Intersystem Crossing in Spirobis[anthracene]diones. Angew. Chem. Int. Ed., 2020, 59, 22179-22184. (IF = 16.6,中科院Itop)

    5)      Chong Cao, Hang Yin, Biao Yang, Qi Yue, Guoqing Wu, Meng Gu, Yuwen Zhang, Yang Fan, Xiaoyan Dong, Ting Wang, Cong Wang, Xiao Zhu*, Ying Mao*, Xiao-Yong Zhang*, Zuhai Lei*, Cong Li*, Intra-operative Definition of Glioma Infiltrative Margins by Visualizing Immunosuppressive Tumor-Associated Macrophages, Adv. Sci. 2023, 2304020. (IF = 15.1,中科院Itop)

    6)      Zuhai Lei, Caixia Sun, Peng Pei, Shangfeng Wang, Dandan Li, Xin Zhang, Fan Zhang*. Stable, Wavelength-Tunable Fluorescent Dyes in the NIR-II Region for In Vivo High-Contrast Bioimaging and Multiplexed Biosensing. Angew. Chem. Int. Ed., 2019, 58, 8166 – 8171. (IF = 16.6,中科院Itop)

    7)      Zuhai Lei, Xinran Li, Xiao Luo, Jing Zheng, Xuhong Qian, and Youjun Yang*. Bright, stable and biocompatible organic fluorophores absorbing/emitting in the deep near-infrared spectral region. Angew. Chem. Int. Ed., 2017, 56, 2979 – 2983. (IF = 16.6,中科院Itop)

    8)      Zuhai Lei, Youjun Yang*. A concise colorimetric and fluorimetric probe for Sarin related threats designed via the covalent-assembly approach. J. Am. Chem. Soc., 2014, 136, 6594−6597. (IF = 15.0,中科院Itop)

    9)      Yunyi Liu, Lu Zhang, Ying Chen, Haitao Sun, Jiajian Chen, Ahmed Mohamed Ei-Toni,Aslam Khan, Zuhai Lei,* and Fan Zhang*, A Reversible NIR-II Ratiometric Fluorescent Probe for Real-Time In Vivo ATP Detection, Adv. Optical Mater. 2023, 230114. (IF = 9.0,中科院I)

    10)  Zuhai Lei, Fan Zhang*. Molecular Engineering of NIR-II Fluorophores for Improved Biomedical Detection. Angew. Chem. Int. Ed., 2021, 60, 16294-16308. (IF = 16.6,中科院Itop)

     

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