田怡婧

邮箱：tianyijing@ynu.edu.cn

职称：讲师

地址：伟德国际1946源于英国呈贡校区伟德BETVlCTOR1946，国家重点实验室

教育经历

2017.09-2022.06，中山大学，伟德BETVlCTOR1946，药物化学，理学博士

2013.08-2017.06，中山大学，伟德BETVlCTOR1946，药学，理学学士

工作经历

2023.04-至今，伟德国际1946源于英国，伟德BETVlCTOR1946，教育部自然资源药物化学重点实验室，讲师

2022.10-2023.04，伟德国际1946源于英国，教育部自然资源药物化学重点实验室，讲师

研究领域

1)      靶向纤维化疾病的天然活性分子研究：结合云南独特的民族药与丰富的植物药物资源，开展新型抗特发性肺纤维化的药物发现以及机制研究。

执教课程与教学成果

主讲《药代动力学》，《药剂学实验》

科研项目

1)      国家自然科学基金面上项目，选择性磷酸二酯酶9型抑制剂的设计、成药性优化及 抗肺纤维化作用研究深度学习驱动的组蛋白修饰酶抑制剂发现，2020-01-01 至 2023-12-31， 参与

代表性论文

1)        Yi-Nuo Wu^#, Yi-Jing Tian^#, Mei-Ling Le^#; Si-Rui Zhang, Chen Zhang, Meng-Xing Huang, Mei-Yan Jiang, Bei Zhang; Hai-bin Luo*. Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis[J]. Journal of Medicinal Chemistry 2020, 63(14): 7867-7879.

2)        Meng-Xing Huang^#, Yi-Jing Tian^#, Chuan Han; Run-Duo Liu, Xi Xie, Yijun Yuan, Yi-Yi Yang, Zhe Li; Yi-Nuo Wu* Hai-bin Luo*. Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects [J]. Journal of Medicinal Chemistry 2022, 65,: 8444-8455.

3)        Yi-You Huang^#, Jin-hui Deng^#, Yi-Jing Tian^#; Jin-hao Liang, Xi Xie, Yue Huang, Jia-qi Zhu, Zi-ran Zhu, Qian Zhou; Xi-xin He*, Hai-Bin Luo*. Mangostanin Derivatives as Novel and Orally Active PDE4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety[J]. Journal of Medicinal Chemistry. 2021, 64, 18, 13736-13751.

4)         Shen Li^#, Lu Gan^#, Yi-Jing Tian, Yang Tian, Run-Zhu Fan, Dong Huang, Fang-Yu Yuan, Xu Zhang, Yan Lin, Qin-Feng Zhu, Gui-Hua Tang, Xue-Long Yan*, Sheng Yin*. Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway[J]. Bioorganic Chemistry, 2021, 114: 105222.

5)        Yi-nuo Wu^#, Quan Wang^#, Mei-Yan Jiang^#, Yi-You Huang, Zi-ran Zhu, Chuan Han, Yi-Jing Tian, Bei Zhang； Hai-Bin Luo*. Discovery of potent phosphodiesterase-9 inhibitors for the treatment of hepatic fibrosis[J]. Journal of Medicinal Chemistry, 2021, 64(13): 9537-9549.

6)         Yao Zhang^#, Run-Zhu Fan^#, Jun Sang, Yi-Jing Tian, Jia-Qi Chen, Gui-Hua Tang, Sheng Yin*. Ingol diterpenoids as P-glycoprotein-dependent multidrug resistance (MDR) reversal agents from Euphorbia marginata[J]. Bioorganic Chemistry, 2020, 95: 103546.