In vivo Realization of Dual Photodynamic and Photothermal Therapy for Melanoma by Mitochondria Targeting Dinuclear Ruthenium Complexes under Civil Infrared Low-power Laser

By:Meng-Fan Wang,Rong Yang,Shi-Jie Tang,Yu-Ang Deng,Guo-Kui Li,Dr. Dan Zhang,Dr. Daomei Chen,Dr. Xiaoxia Ren,Dr. Feng Gao*

Angewandte Chemie International Edition

DOI：https://doi.org/10.1002/anie.202208721

Published：2022-Jul-30

Abstract

Dinuclear ruthenium complexes with high two-photon absorption in the IR region and photothermal conversion efficiency have been developed to target mitochondria without penetrating the nucleus for tumor therapy. They show suppressed melanoma tumor growth in vitro and in vivo with dual two-photon photodynamic and photothermal therapy.