科学研究

    科学研究

    当前您的位置: 首页 - 科学研究 - 正文

    【Org. Lett.】Total Synthesis of Vinorine

    来源: 日期:2023年05月14日 17:07点击:

    Total Synthesis of Vinorine

    By:Kang, Shiyuan; Wu, Yinxia; Hu, Min; Ma, Ying; Huang, Xiangdi; Hao, Zhen; Li, Xiujuan; Chen, Wen*; Zhang, Hongbin*

    Organic Letters

    DOI:10.1021/acs.orglett.3c01041

    Published:2023-May-08

    Abstract

    The asymmetric total synthesis of vinorine, a polycyclic and cage-like alkaloid, has been realized in a flexible approach. Key features of the current synthesis include an aza-Achmatowicz rearrangement/Mannich-type cyclization to install the highly functional 9-azabicyclo-[3.3.1]nonane scaffold, a high yield Fischer indole annulation to synthesize the common intermediate for sarpagine-ajamaline type alkaloids, and an Ireland-Claisen rearrangement to construct the C15-C20 bond.

    全文链接:https://pubs.acs.org/doi/10.1021/acs.orglett.3c01041



    Copyright © 伟德国际BETVLCTOR·1946源自英国(CHINA)官方网站 版权所有        ICP备案号:滇ICP备12004993号-2