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    【Org. Lett.】Iodine(III)-Mediated C-C Bond Coupling to Construct Spirocyclic Indolenines of Various Ring Sizes

    来源: 日期:2023年05月14日 17:13点击:

    Iodine(III)-Mediated C-C Bond Coupling to Construct Spirocyclic Indolenines of Various Ring Sizes

    By: Zhu, Yanren; Yang, Shaoxiong; Pu, Enfan; Li, Li; Ye, Silei; Wei, Longsheng; Ma, Guolan; Zhang, Yushun; Zhang, Hongbin*; Chen, Jingbo*

    Organic Letters

    DOI:https://doi.org/10.1021/acs.orglett.3c01106

    Published:2023-May-08

    Abstract

    Herein, we report a novel iodine(III)-mediated intramolecular dearomative spirocyclization of indole derivatives to generate highly strained spirocyclobutyl, spirocyclopentyl, and spirocyclohexyl indolenines in moderate to good yields. A set of structurally novel, densely functionalized spiroindolenines with broad functional group compatibility was efficiently constructed in this way under mild reaction conditions. Moreover, the beta-enamine ester as a versatile functional group in the product provides great convenience for the synthesis of bioactive compounds and related natural products.

    全文链接:https://pubs.acs.org/doi/10.1021/acs.orglett.3c01106



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