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    【Biomed. Pharmacother.】Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

    来源: 日期:2023年08月01日 11:04点击:

    Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

    By:Peng Tang, Tianze Shen, Hairong Wang, Ruihan Zhang, Xingjie Zhang, Xiaoli Li, Weilie Xiao

    Biomedicine & Pharmacotherapy

    DOI:https://doi.org/10.1016/j.biopha.2023.114955

    Published:2023-Aug

    Abstract

    Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the secondary metabolites of organisms and have been the most famous drug discovery database. Bioactive natural products are famous for their enormous number and great safety in medical applications. However, BNPs are troubled by their poor druggability compared with synthesis drugs and are challenged as medicine (only a few BNPs are applied in clinical settings). In order to find a reasonable solution to improving the druggability of BNPs, this review summarizes their bioactive nature based on the enormous pharmacological research and tries to explain the reasons for the poor druggability of BNPs. And then focused on the boosting research on BNPs loaded drug delivery systems, this review further concludes the advantages of drug delivery systems on the druggability improvement of BNPs from the perspective of their bioactive nature, discusses why BNPs need drug delivery systems, and predicts the next direction.


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