FeCl3-catalyzed oxidative amidation of benzylic C-H bonds enabled by a photogenerated chlorine-radical
By: Yingying Yang, Xianglin Yu, Na He, Xinxiang Huang, Xizhong Song, Jingbo Chen, Jun Lin and Yi Jin
Chemical Communications
DOI：https://doi.org/10.1039/d3cc03186a
Published：2023-July-27
Abstract
Herein, we report the development of iron-catalyzed benzylic C-H oxidative amidation reactions via photoinduced ligand-to-metal charge transfer (LMCT). These reactions exhibit a broad substrate scope (60 examples) and offer operationally simple, scalable procedures for accessing valuable products from methylarenes in a single step. Mechanistic studies and control experiments confirm the participation of a photogenerated chlorine radical in facilitating the hydrogen atom transfer (HAT) from the benzylic C-H bond to initiate the reaction.
